IFNL4 and donor selection for matched unrelated donor haematopoietic stem-cell transplantation
نویسندگان
چکیده
منابع مشابه
Donor-derived mycosis fungoides following reduced intensity haematopoietic stem cell transplantation from a matched unrelated donor
A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in vivo T-cell-depleted allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor. Following the transplantation, she developed recurrent cutaneous graft versus host disease (GvHD), which required treatment w...
متن کاملDonor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation.
Anti-HLA donor-specific Abs (DSAs) have been reported to be associated with graft failure in mismatched hematopoietic stem cell transplantation; however, their role in the development of graft failure in matched unrelated donor (MUD) transplantation remains unclear. We hypothesize that DSAs against a mismatched HLA-DPB1 locus is associated with graft failure in this setting. The presence of ant...
متن کاملUnrelated donor haematopoietic stem cell transplantation for adult patients with haematological malignancies.
Unrelated donor (URD) is an acceptable source of stem cell grafts for adults. With the growth in available URD, improved human leukocyte antigen (HLA) typing technology and better understanding of HLA matching, the number of URD haematopoietic stem cell transplantation (URD-HSCT) is increasing dramatically in recent years. Peripheral blood stem cells have surpassed bone marrow as the preferred ...
متن کاملAllogeneic haematopoietic stem cell transplantation without a matched sibling donor: current options and future potential.
INTRODUCTION Allogeneic haematopoietic stem cell transplantation (HSCT) has been used to treat a variety of malignant and non-malignant diseases. For patients who do not have a matched sibling donor or a optimally matched unrelated donor (MUD) for transplantation, other graft sources have been used, including mismatched haploidentical related donors and umbilical cord blood (CB). MATERIALS AN...
متن کاملDecision analysis for donor selection in stem cell transplantation—HLA-8/8 allele-matched unrelated donor vs HLA-1 AG mismatched related donor
Risk of relapse during the unrelated donor coordination period biases comparisons between allogeneic hematopoietic stem cell transplantation from an HLA 8 of 8 allele-matched unrelated donor (8/8 MUD) and that from a related donor with an HLA-1 antigen mismatch in the graft-versus-host (GVH) direction (RD/1AGMM-GVH). To reduce this bias, we performed a decision analysis focusing on acute myeloi...
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ژورنال
عنوان ژورنال: The Lancet Haematology
سال: 2020
ISSN: 2352-3026
DOI: 10.1016/s2352-3026(20)30287-8